Understanding the mechanism
of action & science

Alpha-Stim® M and Alpha-Stim AID devices utilize cranial electrotherapy stimulation (CES) and microcurrent electrical therapy (MET). Learn more about the mechanism of action and science behind both technologies below.

How Alpha-Stim Works for Anxiety, Insomnia, Depression* & Pain

Cranial Electrotherapy Stimulation (CES) for anxiety, insomnia, and depression, and Microcurrent Electrical Therapy (MET) for pain.

Alpha-Stim CES is a form of non-invasive brain stimulation that applies a patented, low amplitude waveform to the brain via earclip electrodes. Psychiatric disorders, such as anxiety and insomnia, are associated with alterations in electric activity in large-scale brain networks. Research suggests that Alpha-Stim CES modulates large-scale brain network activity patterns in two synergistic ways:

Ultimately, these two ways of stimulating the brain normalize the pathological signaling in the default mode network observed in psychiatric disorders, providing rapid, effective, and lasting symptom relief without the side effects of medication.

MET is the process of directing microcurrent through the body via Smart Probes or self-adhesive AS-Trodes to treat pain. When applied peripherally, the rhythmic, low-amplitude current of Alpha-Stim MET modulates the peripheral signaling in pain circuits that emanate from the spinal cord, providing rapid, effective, and lasting pain relief with no risk of addiction or tolerance.

  • Alpha-Stim M: Microcurrent is delivered via electrodes placed on the body at the pain site for the treatment of acute, chronic, and post-traumatic pain using MET. Also includes earclip electrodes for CES to treat anxiety, insomnia, and depression.
  • Alpha-Stim AID: Microcurrent is transmitted to the brain via earclip electrodes using CES to treat anxiety, insomnia, and depression.*

*FDA cleared for anxiety, insomnia and pain only, with approval for depression outside of the United States. 

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Discover Alpha-Stim technology today.

Alpha-Stim M

Alpha-Stim® M

For anxiety, insomnia, depression and pain.

Alpha-Stim AID

Alpha-Stim® AID

For anxiety, insomnia and depression.

The Alpha-Stim Difference

Alpha-Stim can be safely delivered at home and is better tolerated than more expensive and burdensome alternatives. It also increases treatment motivation and thereby augments treatment response as it offers the patient agency over their recovery process by adjusting stimulation parameters.

Alpha-Stim can be performed at any time during a wide range of daily activities, allowing a patient to live an active and uninterrupted lifestyle.

Getting Started with Alpha-Stim

Want to try Alpha-Stim AID or M devices with your patients? To help new health practitioners see if Alpha-Stim is a good fit for their patients we offer options with both devices for trying them out. Use the form below to get more information about Alpha-Stim. 


Proven Results for Patients Everywhere

How can I get Alpha-Stim for patients?

Alpha-Stim technologies are easy to use with patients. Alpha-Stim can be prescribed both in-person in a qualified healthcare clinic or office setting, as well as via telehealth appointments.

Learn about prescribing Alpha-Stim below.

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